Pediatric lipid screening rates and awareness of FH are limited in the US1

Although HeFH occurs in 1 in ~250 individuals and HoFH in 1 in ~250,000 individuals, the true prevalence of FH may not be grasped, as the more common heterozygous form is often asymptomatic in nature.1-5 Discover the actionable steps to raise awareness of FH and its rare form, HoFH.

The importance of early FH diagnosis

Dr Don P. Wilson, MD, FNLA, and Dr Jason V. Terk, MD, discuss the underdiagnosis of FH despite its prevalence in the US, and how to help support its diagnosis in practice.

Guidelines and recommendations​

Further reading for more information on pediatric lipid screening and FH diagnosis.

The National Heart, Lung and Blood Institute: Guidelines for cardiovascular health and risk reduction in children and adolescents​

Guidelines recommend lipid screening for all children aged between 9 and 11 years. Screening may be performed as early as age 2 if there is a family history of high blood cholesterol levels, heart attack, or stroke.6

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The American Heart Association: The agenda for familial hypercholesterolemia

Recommendations for heterozygous FH and homozygous FH diagnosis​.5

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The organizations listed are independent non-profit organizations.
Their inclusion here does not imply endorsement by Regeneron nor does it imply their endorsement of Regeneron or this resource center.

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References

  1. de Ferranti SD et al. J Pediatr 2017;185:99–105.​

  2. McGowan MP et al. J Am Heart Assoc 2019;8:e013225.​

  3. Raal FJ et al. Atherosclerosis 2018;277:483–492.

  4. Cuchel M et al. Eur Heart J 2023;44:2277-2291.

  5. Gidding SS et al. Circulation 2015;132:2167–2192.

  6. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents. Pediatrics 2011;128:S213–S256.